Nexium 47

+

(Nexium),,, 3D-(3) 10 / Al / 1 3042,7, 28 EAN: 7.321.838,74186 milioni -001.170, 2011-11-11 AstraZeneca UK Ltd. (): AstraZeneca AB () 10 / Al / 1 3042,7, 28 - 001170, 2011-11-11 AstraZeneca UK Ltd. (): AstraZeneca AB (): Corden Pharma GmbH () 10 / Al / 1 3042,7, 28 -001.170, 2011-11-11 AstraZeneca UK Ltd. (): AstraZeneca AB ( ): - () (5) 40 (), 10 EAN: 7.321.838,731403 millions -000.920, 2005-11-18 AstraZeneca AB () 2010-11-18 40 () 1, 10 EAN: 4.670.012,610144 millions -000.920, 2011-04-01 AstraZeneca AB () 40 (), 10 EAN: 7.321.838,731403 millions -00.920, 2011-04-01 AstraZeneca UK Ltd. (): AstraZeneca AB () 40 (), 10 EAN: 4.607.155,430384 millions -00.920, 2011-04-01 AstraZeneca UK Ltd . (): AstraZeneca AB (): Corden Pharma GmbH () 40 () 1, 10 EAN: 4.606.556,002534 millions -00.920, 2011-04-01 AstraZeneca UK Ltd. (): AstraZeneca AB (): (), (22), 20 7, 2 EAN: 7.321.838,741877 millions N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, 2 EAN: 7.321.838,741921 millions N013775 / 01, 2007-05-31 AstraZeneca AB (), 20 7, 1 EAN: 7.321.838,74186 milioni N013775 / 01, 2007-05-31 AstraZeneca AB (): Corden Pharma GmbH (), 20 7, 4 N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, 1 N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, 4 N013775 / 01, 2007-05-31 AstraZeneca AB (), 20 7, 2 EAN: 4.607.085,315447 millions N013775 / 01, 2007-05-31 AstraZeneca AB (): - (), 40 7 , 2 EAN: 4.607.085,315478 millions N013775 / 01, 2007-05-31 AstraZeneca AB (): - (), 20 7, 1 EAN: 4.607.085,31543 milioni N013775 / 01, 2007-05-31 AstraZeneca AB (): - (), 20 7 , 4 EAN: 4.607.085,315454 millions N013775 / 01, 2007-05-31 AstraZeneca AB (): - (), 40 7, 4 EAN: 4.607.085,315485 millions N013775 / 01, 2007-05-31 AstraZeneca AB (): - (), 40 7 , 4 EAN: 4.607.085,315485 millions N013775 / 01, 2007-05-31 AstraZeneca AB (): Corden Pharma GmbH (), 20 7, alla rinfusa 1 N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, alla rinfusa 1 N013775 / 01, 2007-05-31 AstraZeneca AB (), 20 7, 2 N013775 / 01, 2007-05-31 AstraZeneca AB (): Corden Pharma GmbH (), 20 7, 4 N013775 / 01, 2007-05 -31 AstraZeneca AB (): Corden Pharma GmbH (), 20 7, 2 N013775 / 01, 2007-05-31 AstraZeneca AB (), 20 7, 4 N013775 / 01, 2007-05-31 AstraZeneca AB (), 20 7, 1 N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, 1 N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, 4 N013775 / 01, 2007-05-31 AstraZeneca AB (), 40 7, 2 N013775 / 01, 2007-05-31 AstraZeneca AB () (20/40): 40 10/14, 20:, -,, 20 mg A / EH. , 40:,,, 40 mg A / EI. (). -. S - . S R-. , /,,. 1 20 40. 5 20 1 C max 90 (67 5-). 5 20 40 4, 13 17 24. 20/4 8, 12 16 76, 54 24. 40 97, 92 56. (AUC). ,. 40-78 4 93 8. 20 2 90 Helicobacter pylori. ,,. ,. ,. ,,. (CgA). CgA. 514 CgA. CgA,. ,,,. . ,,,. . . ,, ..,,. . Salmonella spp. Campylobacter spp. . Clostridium difficile (). ,. -2. , (60 /), -2. . ,,,. in vivo R-. : C max 12. 40 64 89 1. 20 50 68. V ss 0,22 /. 97.,. . 450. Y219. . CYP3A4,,. ,, CYP2C19. Cl 17 /, 1,3 1. AUC. AUC,,,, CYP2C19 /. 1. . 80,. 1. CYP2C19. (2,91,5) CYP2C19. CYP3A4. 40 U 100 CYP2C19. C max 60.. . (7180). . 40 U 30. 1. . . . , U 2. . . ,,,. . 1218 20 40 max U T max U T. : - - - - - (): -, Helicobacter pylori -, Helicobacter pylori, (/,),,: -, -,. , -, ... ,,, - - (.) 12 () 12 (,). : (). . ,,. -. -,,. ,. ,,. ,,. ,. : (1/10000). :, -,. -:. :. :,. :. :,. :. :,. : (,, /). ,:. :. :. :,. :,. . ,. ,,,,. 20 1 10 (30 2 10). ,. . . CYP2C19. ,,. . (40 1) 300/100 (AUC. C max C min 75). 400. ,. ,,,. CYP2C19,. ,, CYP2C19. ,,,,. ,. . 30, CYP2C19. 45. 40 13.. 40 1 AUC C max (CYP2C19) 15 41. 40,. . . / (75 /) (40 /.), 40 - 14. , 20 / () -,. -. 20 81 40, -,,,. 40 C max AUC 18 26 29 69. 40: 31 AUC, C max. QT. , (.). . . . . . . CYP2C19 CYP3A4. (500 2), CYP34. AUC 2. CYP34 CYP2C19. , 2- AUC. ,. . , CYP2C19 CYP3A4. ,. . ,. . ... 30. ,. . ,,. ,. . 12 -: 40 1 4. 4-,. -: 20 1. : 20 1. 4,. .. 20 1. ,,. (), Helicobacter pylori: 20, 1 500. 2 1. , Helicobacter pylori: 20, 1 500. 2 1. , (/,), 40 1 4 /,. ,,: 20 40 1. 48. ,: 20 40 1. ,, .. - 40 2. ,. 120 2. :. (.). :. 20. :. 1. 25 5. 50,. 2. 2. 3.,. 4.,. 5.. 510. (). 6. 510. ,. 7., 25 5, 5 6. 50. :. 280. 80 -. :. ,. . (,,,), (),. ,,. , (1),. ,,. , (.). Helicobacter pylori. CYP34. ,, CYP34 (),. ,, - -. , / (300 75 /) (40 /.), 40 - 14. (.). ,,. , (12),. - /,. . ,,,. ,, 20 40. 7. . 1, 2 4. ,: 7. , 1, 2 4. -,. 7. , 1, 2 4. 7. , 1, 2 4. , SE-151 85,. 1., SE-151 85,. 2., -, D-68723,. 3. -. 142103,,. ,. . , 2.:,,: 125284,,. , 3,. 1.. 7- (495) -799-56-99: 7- (495) -799-56-98. 30 C.. ,.